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The WHO Covid-19 Research Database is a resource created in response to the Public Health Emergency of International Concern (PHEIC). Its content remains searchable and spans the time period March 2020 to June 2023. Since June 2023, manual updates to the database have been discontinued.

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Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system.

de Queiroz, Nina Marí G P; Marinho, Fabio V; Chagas, Marcelo A; Leite, Luciana C C; Homan, E Jane; de Magalhães, Mariana T Q; Oliveira, Sergio C.

Microbes Infect ; 22(10): 515-524, 2020.

Article in English | MEDLINE | ID: covidwho-779460

ABSTRACT

This article discusses standard and new disruptive strategies in the race to develop an anti-COVID-19 vaccine. We also included new bioinformatic data from our group mapping immunodominant epitopes and structural analysis of the spike protein. Another innovative approach reviewed here is the use of BCG vaccine as priming strategy and/or delivery system expressing SARS-CoV-2 antigens.

Subject(s)

BCG Vaccine/administration & dosage , COVID-19 Vaccines/immunology , COVID-19/immunology , SARS-CoV-2/immunology , Spike Glycoprotein, Coronavirus/immunology , Vaccines, DNA/immunology , Viral Vaccines/immunology , Angiotensin-Converting Enzyme 2/chemistry , Antibodies, Viral/immunology , COVID-19/prevention & control , Epitope Mapping , Humans , Middle East Respiratory Syndrome Coronavirus/chemistry , Protein Binding , Spike Glycoprotein, Coronavirus/chemistry

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